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Alternative splicing and transcription elongation in plants
(Frontiers Media S.A., 2019-03)
Alternative splicing and transcription elongation by RNA polymerase II (RNAPII) are two processes which are tightly connected. Splicing is a co-transcriptional process, and different experimental approaches show that ...
Alternative splicing switches: Important players in cell differentiation
(John Wiley & Sons Inc, 2017-06-27)
Alternative splicing (AS) greatly expands the coding capacities of genomes by allowing the generation of multiple mature mRNAs from a limited number of genes. Although the massive switch in AS profiles that often accompanies ...
Global transcriptome analysis reveals circadian control of splicing events in Arabidopsis thaliana
(Wiley Blackwell Publishing, Inc, 2020-05)
The circadian clock of Arabidopsis thaliana controls many physiological and molecular processes, allowing plants to anticipate daily changes in their environment. However, developing a detailed understanding of how ...
Splicing regulation by long noncoding RNAs
(Oxford University Press, 2018-02)
Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly ...
Chromatin, DNA structure and alternative splicing
(Elsevier Science, 2015-06)
Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II ...
Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition
(Nature Research, 2021-12)
Alternative splicing relies on the combinatorial recruitment of splicing regulators to specific RNA binding sites. Chromatin has been shown to impact this recruitment. However, a limited number of histone marks have been ...
Linking transcription, RNA polymerase II elongation and alternative splicing
(Journal of the Serbian Chemical Society, 2020-08-28)
Gene expression is an intricately regulated process that is at the basis of cell differentiation, the maintenance of cell identity and the cellular responses to environmental changes. Alternative splicing, the process by ...
The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators
(Oxford University Press, 2016-10-17)
Alternative splicing (AS) is a key component of gene expression programs that drive cellular differentiation. Smooth muscle cells (SMCs) are important in the function of a number of physiological systems; however, investigation ...
Epigenetics in Alternative Pre-mRNA Splicing
(Cell Press, 2011-01)
Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused ...
CTCF: from insulators to alternative splicing regulation
(Nature Publishing Group, 2012-02)
The zinc-finger DNA-binding protein CTCF has been known for being a constituent of insulators. A recent paper in Nature reports an unforeseen intragenic role for CTCF that links DNA methylation with alternative splicing. ...